Substrate Length Controls Atropopeptide Complexity and Triggers Excision-Driven Scaffold Hop to Diketopiperazine Alkaloids | J. Am. Chem. Soc. | 2026
A Machine Learning-Based Genome Mining Approach Reveals Unprecedented Biarylitide Diversity | JACS Au | 2026
Discovery of Pyranoquinolone Diterpenoids Biosynthesized through Oxidative Indole Rearrangement and Atypical Terpene Cyclization | J. Am. Chem. Soc. | 2026
antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation | Nucleic Acids Res. | 2025
3-Hydroxypropionate production from myo-inositol by the gut acetogen Blautia schinkii | Environ. Microbiol. | 2024
Phylogeny-guided discovery of a promiscuous P450 macrocyclase for the production of diverse atropopeptides | Chemical Science | 2025
The role and mechanisms of canonical and non-canonical tailoring enzymes in bacterial terpenoid biosynthesis | Natural Product Reports | 2025
MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration | Nucleic Acids Res | 2025
Exploration, expansion and definition of the atropopeptide family of ribosomally synthesized and posttranslationally modified peptides | Chemical Science | 2024
Functional Redundancy and Dual Function of a Hypothetical Protein in the Biosynthesis of Eunicellane-Type Diterpenoids | ACS Chemical Biology | 2024
RAIChU: automating the visualisation of natural product biosynthesis | Journal of Cheminformatics | 2024
Genombasierte Wege zur Identifikation bioaktiver bakterieller Naturstoffe | BIOspektrum | 2024
Chromosome-level genome assembly of the sacoglossan sea slug Elysia timida (Risso, 1818) | BMC genomics | 2024
Artificial intelligence for natural product drug discovery | Nat Rev Drug Discov | 2023
Better integration of chemical pollution research will further our understanding of biodiversity loss | Nat Ecol Evol | 2023
antiSMASH 7.0: New and improved predictions for detection, regulation, chemical structures and visualisation | Nucleic Acids Res | 2023
MIBiG 3.0: A Community-driven Effort to Annotate Experimentally Validated Biosynthetic Gene Clusters | Nucleic Acids Res | 2023
A Microbiome-Dependent Gut–Brain Pathway Regulates Motivation for Exercise | Nature | 2022
Navigating and Expanding the Roadmap of Natural Product Genome Mining Tools | Beilstein J. Org. Chem. | 2022
Atropopeptides are a Novel Family of Ribosomally Synthesized and Posttranslationally Modified Peptides with a Complex Molecular Shape | Angew. Chem. Int. Ed. | 2022
Complex peptide natural products: Biosynthetic principles, challenges and opportunities for pathway engineering | Synth Syst Biotechnol | 2022
Bacillimidazoles A−F, Imidazolium-Containing Compounds Isolated from a Marine Bacillus | Mar. Drugs | 2022
Modular Halogenation, α-Hydroxylation, and Acylation by a Remarkably Versatile Polyketide Synthase | Angew. Chem. Int. Ed. | 2022
Hidden Treasures: Microbial Natural Product Biosynthesis off the Beaten Path | mSystems | 2021
Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria | Nature Communications | 2021
A community resource for paired genomic and metabolomic data mining | Nature Chemical Biology | 2021
Specialized Metabolites Reveal Evolutionary History and Geographic Dispersion of a Multilateral Symbiosis | ACS Central Science | 2021
A multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheli | Proceedings of the National Academy of Sciences | 2020
Research Tales from the Clardy Laboratory: Function-Driven Natural Product Discovery | Journal of Natural Products | 2020
Total synthesis reveals atypical atropisomerism in a small-molecule natural product, tryptorubin A | Science | 2020
Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A | Chemical Communications | 2020
Bacterial terpene biosynthesis: challenges and opportunities for pathway engineering | Beilstein Journal of Organic Chemistry | 2019
Pyonitrins A–D: Chimeric Natural Products Produced by Pseudomonas protegens | Journal of the American Chemical Society | 2019
Automated structure prediction of trans-acyltransferase polyketide synthase products | Nature Chemical Biology | 2019
In plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids | Nature Microbiology | 2019
A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones | Angewandte Chemie | 2018
Bipartite interactions, antibiotic production and biosynthetic potential of the Arabidopsis leaf microbiome | Nature Microbiology | 2018
An Unusual Flavin-Dependent Halogenase from the Metagenome of the Marine Sponge Theonella swinhoei WA | ACS Chemical Biology | 2017
Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges | Proceedings of the National Academy of Sciences | 2017
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking | Nature Biotechnology | 2016
Metabolic footprint of epiphytic bacteria on Arabidopsis thaliana leaves | The ISME Journal | 2016
Biosynthesis of polyketides by trans-AT polyketide synthases | Natural Product Reports | 2016
Minimum Information about a Biosynthetic Gene cluster | Nature Chemical Biology | 2015
Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms | Nature Chemical Biology | 2015
Nostopeptolide plays a governing role during cellular differentiation of the symbiotic cyanobacterium Nostoc punctiforme | Proceedings of the National Academy of Sciences | 2015
Recent advances in genome-based polyketide discovery | Current Opinion in Biotechnology | 2014
Matrix-free single-cell LDI-MS investigations of the diatoms Coscinodiscus granii and Thalassiosira pseudonana | Journal of Mass Spectrometry | 2014
An environmental bacterial taxon with a large and distinct metabolic repertoire | Nature | 2013
Genome Mining Reveals trans‐AT Polyketide Synthase Directed Antibiotic Biosynthesis in the Bacterial Phylum Bacteroidetes | ChemBioChem | 2010
